Alzheimer’s Horizon 2025

7.2M
U.S. Patients (2025)
Alzheimer’s Assoc.
$384B
Annual Care Costs
2025 Facts & Figures
90%
Test Precision (p-tau217)
NIH / JAMA
138+
Drugs in Pipeline
ClinicalTrials.gov

Prevalence Trend Source: US Census / Alz. Assoc.

The $800B Burden Direct vs. Unpaid

Unpaid care valued at $413.5B (19.2B total hours)

Biological Hallmarks

🧠

Amyloid Beta Plaques

Hyperphosphorylated Tau

40% Modifiable Risk Factors Source: Lancet Commission

🫀
Vascular
Hypertension
🥗
Lifestyle
Exercise/Diet
👂
Sensory
Hearing Loss
📚
Education
Cognitive Reserve

Memory Care Impact: Preserving Independence

Independence Gain
4.7 – 7.5 Mo.
Delay in progressing to dependency
ADL Preservation
40% Slower
Loss of self-care skills (ADCS-ADL)

Clinical Insight: Beyond cognitive scores, memory-care data focus on Functional Independence. Modern therapies have shown a significant slowing in the decline of daily activities such as dressing, bathing, and managing finances, granting families more “high-quality” time before high-acuity care is required.

Academic & Statistical Sources

• Alzheimer’s Association: 2025 Alzheimer’s Disease Facts and Figures (Prevalence and Costs).

• JAMA Neurology: Accuracy of p-tau217 Blood Tests for Alzheimer’s Diagnosis (2024-25 Reports).

• NEJM & iADRS Data: Preservation of Daily Functioning and Memory Quality in TRAILBLAZER-ALZ 2 trials.

• NIH Research Progress: 2025 Alzheimer’s Disease and Related Dementias Report.